Aurora A kinase

4UZH, 1MQ4, 1MUO, 1OL5, 1OL6, 1OL7, 2BMC, 2C6D, 2C6E, 2DWB, 2J4Z, 2J50, 2NP8, 2W1C, 2W1D, 2W1E, 2W1F, 2W1G, 2WQE, 2WTV, 2WTW, 2X6D, 2X6E, 2X81, 2XNE, 2XNG, 2XRU, 3COH, 3E5A, 3EFW, 3FDN, 3H0Y, 3H0Z, 3H10, 3HA6, 3K5U, 3LAU, 3M11, 3MYG, 3NRM, 3O50, 3O51, 3P9J, 3QBN, 3R21, 3R22, 3UNZ, 3UO4, 3UO5, 3UO6, 3UOD, 3UOH, 3UOJ, 3UOK, 3UOL, 3UP2, 3UP7, 3VAP, 3W10, 3W16, 3W18, 3W2C, 4B0G, 4BN1, 4BYI, 4BYJ, 4C3P, 4C3R, 4CEG, 4DEA, 4DEB, 4DED, 4DEE, 4DHF, 4J8M, 4J8N, 4JAI, 4JAJ, 4JBO, 4JBP, 4JBQ, 4O0S, 4O0U, 4O0W, 4PRJ, 4UYN, 4UZD, 4UTD, 5AAD, 5AAE, 5AAF, 5AAG, 5EW9, 5DR9, 5DPV, 5DN3, 5DRD, 5L8J, 4ZS0, 5DR6679020878ENSG00000087586ENSMUSG00000027496O14965P97477NM_198437NM_001323303NM_001323304NM_001323305NM_011497NM_001291185NP_940836NP_940837NP_940838NP_940839NP_001278114NP_035627Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.1mq4: Crystal Structure of Aurora-A Protein Kinase1muo: CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE1ol5: STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-431ol6: STRUCTURE OF UNPHOSPHORYLATED D274N MUTANT OF AURORA-A1ol7: STRUCTURE OF HUMAN AURORA-A 122-403 PHOSPHORYLATED ON THR287, THR2882bmc: AURORA-2 T287D T288D COMPLEXED WITH PHA-6806322c6d: AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH ADPNP2c6e: AURORA A KINASE ACTIVATED MUTANT (T287D) IN COMPLEX WITH A 5-AMINOPYRIMIDINYL QUINAZOLINE INHIBITOR2j4z: STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-6806262j50: STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-7393582np8: Structural Basis for the Inhibition of Aurora A Kinase by a Novel Class of High Affinity Disubstituted Pyrimidine Inhibitors Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. The aurora kinases were first identified in 1990 during a cDNA screen of Xenopus eggs. The kinase discovered, Eg2, is now referred to as Aurora A. It was not until 1998, however, that Aurora A's meiotic and mitotic importance was realized. The human genome contains three members the Aurora kinase family: Aurora A kinase, Aurora B kinase and Aurora C kinase. The Xenopus, Drosophila, and Caenorhabditis elegans genomes, on the other hand, contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the centrosome during different phases of mitosis. The family members have highly conserved C-terminal catalytic domains. Their N-terminal domains, however, exhibit a large degree of variance in the size and sequence. Aurora A and Aurora B kinases play important roles in mitosis. The Aurora A kinase is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. The Aurora B kinase is a chromosome passenger protein and regulates chromosome segregation and cytokinesis.