Glycal-Mediated Synthesis of Enantiomerically Pure 5-Substituted Isoxazoles Containing a Differentially O-Benzylated Glycerol Moiety.

A short, glycal-mediated synthesis of new chiral 5-substituted isoxazoles bearing a differentially O-protected glycerol moiety in the side chain has been accomplished. An X-ray crystallographic structural analysis confirmed the structural assignment of the new products.