Study on the Influence of a Sustainable Medium for the Design of Multistep Processes: Three-Component Synthesis of 2-Nitroamines

An environmentally benign method was developed for the three-component, one-pot synthesis of 2-nitroamines by heating a solution of an aldehyde, an aromatic amine, and a nitroalkane in 20% water–methanol at 60 °C for five hours in the absence of a catalyst.