DEPOT-SYNERGETICS OF THE DECREASE IN CHAOTIZATION PREDICTS AND SUBSTANTIATES NOVEL METHODS OF TREATMENT OF CARDIOSCLEROSIS

A mathematical model of energy metabolism is proposed. According to the author’s metabolic reconstruction of heart pathobiochemistry, it is suggested in the model that the mechanism triggering cardiosclerosis (appearance of nonworking regions in the myocardium, which enhance cardiac insuffi ciency) is the autoinfl ammatory process, which is induced by a slow (weeks and years) «incorrec» interaction between the depots of carbohydrates and fats. The model enables one to make a prediction that, in particular slow scenarios of the training and protection of the heart by cytoprotectors from free radicals in stress, a decrease in chaotization may occur and the so-called conditions of preconditioning may arise that are closely associated with the conditions providing the restoration of cardiocytes on the basis of stem cells and cambium. The model hypothesis is confi rmed by clinical trials of Prof. A.E. Gorbunov, Prof. A.N. Fleischman, and Dr. G.N. Gretz.