A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis

Chie Miyabe,Yoshishige Miyabe,Takaki Komiya,Hiroki Shioya,Noriko N. Miura,Kei Takahashi,Naohito Ohno,Ryoji Tsuboi,Andrew D. Luster,Shinichi Kawai,Nobuyuki Miyasaka,Toshihiro Nanki

A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis

2017

Chie Miyabe
Yoshishige Miyabe
Takaki Komiya
Hiroki Shioya
Noriko N. Miura
Kei Takahashi
Naohito Ohno
Ryoji Tsuboi
Andrew D. Luster
Shinichi Kawai
Nobuyuki Miyasaka
Toshihiro Nanki

Objectives Sphingosine 1-phosphate (S1P) is a bioactive lipid that binds to cell surface receptors (S1P1–5). In this study, we examined the effect of S1P1 agonist, ONO-W061, on murine Candida albicans water-soluble fraction (CAWS)-induced vasculitis.

Keywords:

Biology
Biochemistry
Sphingosine-1-phosphate
Vasculitis
Agonist
Sphingosine-1-phosphate receptor
Candida albicans
Cell surface receptor
Chemokine
Sphingosine

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