Notch One Up to Stroma: Endothelial Notch Prevents Inflammation and Myeloproliferation

In this issue of Cell Stem Cell , Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production, which promotes a myeloproliferative phenotype.