Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

Alan D. Bolnick,Mohammed Abdulhasan,Brian A. Kilburn,Yufen Xie,Mindie Howard,Paul Andresen,Alexandra Shamir,Jing Dai,Elizabeth Puscheck,Eric Secor,Daniel A. Rappolee

Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress

2017

Alan D. Bolnick
Mohammed Abdulhasan
Brian A. Kilburn
Yufen Xie
Mindie Howard
Paul Andresen
Alexandra Shamir
Jing Dai
Elizabeth Puscheck
Eric Secor
Daniel A. Rappolee

Purpose This study tests whether metformin or diet supplement BR-DIM-induced AMP-activated protein kinase (AMPK) mediated effects on development are more pronounced in blastocysts or 2-cell mouse embryos.

Keywords:

Biology
Blastocyst
Metformin
Endocrinology
Protein kinase A
Internal medicine
Anabolism
Cell
Embryo
AMPK
Fertility drugs

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