Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

Gondi Kumar,Venkata Jayanti,Marianne K. Johnson,John T. Uchic,Samuel Thomas,Ronald D. Lee,Brian Grabowski,Hing L. Sham,Dale J. Kempf,Jon F. Denissen,Kennan C. Marsh,Eugene Sun,Stanley Roberts

Metabolism and Disposition of the HIV-1 Protease Inhibitor Lopinavir (ABT-378) Given in Combination with Ritonavir in Rats, Dogs, and Humans

2004

Gondi Kumar
Venkata Jayanti
Marianne K. Johnson
John T. Uchic
Samuel Thomas
Ronald D. Lee
Brian Grabowski
Hing L. Sham
Dale J. Kempf
Jon F. Denissen
Kennan C. Marsh
Eugene Sun
Stanley Roberts

Purpose. The objective of this study was to examine the metabolism and disposition of the HIV protease inhibitor lopinavir in humans and animal models.

Keywords:

Drug interaction
Ritonavir
HIV Protease Inhibitor
Metabolism
Lopinavir
HIV-1 protease
Animal model
Biochemistry
Disposition
Pharmacology
Chemistry
pharmacology toxicology

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