Особенности состояния клеточного и гуморального иммунитета и уровни концентрации цитокинов у больных с распространенным гнойным перитонитом

There were investigated the immunological parameter in patients with extensive purulent peritonitis (EPP). It was found that the state of cellular component of immune system at EPP is defined by decreasing in the number of T-, NKand NKT-cells, but at increase in the content of Th2 cells and B1-lymphocytes. The state of humoral immune system in the EPP is characterized by increasing of Ig A and Ig G. When the concentration of IL-1β, IL-6, IFN-γ and TNF-α in the blood of patients with EPP is increased, the mechanisms of interrelation of cytokines of cellular and humoral immunity are violated, that seems to be associated with disturbances in the differentiation and maturation of cells of the immune system as well as the migration of cells in the area of inflammation.