Вплив лізату клітин кісткового мозку на біохімічні показники крові мишей та розвиток аденокарциноми Ерліха

The paper presents the results of investigation of influence of bone marrow cells lysate from mouse (BMCm) on blood biochemistry and development of tumor on transplantable Ehrlich carcinoma model in Balb2 mices. As a result, it was found that injection of BMCm lysate inhibited growth of a solid form of Ehrlich carcinoma in the thigh muscle of experimental animals by 16 % after a single dose, and at 31 % at the multiple procedures. It has been found that the infusion of stem cells mass decreased rate of tumor growth by 37 %. The tumor has not occurred in 10 % of animals. In addition, the injection of BMCm lysate contributed normalization of some indicators of blood chemistry test of animals. Thus, the total protein increased only in 15-18 % after a single dose of BMCm lysate injection and remained normal during multiple procedures. Albumin level decreased by 29,5 % after a single injection of BMCm lysate. When repeated, this procedure led to normalization of albumin level. ALT activity in a single BMCm lysate injection group increased to 103-137 %, while in multiple injections group ALT activity was only by 48-73 % higher than in control samples. Confirmation of normalization of thigh tissue structure was also obtained in histological observation. These data demonstrated the antitumor effect of inactivated lysate of BMCm on the Ehrlich carcinoma model.