Relationship between vaginal intraepithelial neoplasia and TCT, high-risk HPV infection and cervical lesions

Objective To investigate the relationship between vaginal intraepithelial neoplasia (VAIN) and thin-cytologic test (TCT), high-risk human papillomavirus (HR-HPV) infection and cervical lesions. Methods A total of 108 patients with VAIN diagnosed by colposcopy and histological examination due to abnormal cytological screening from May 2016 to September 2018 in Guangdong Maternal and Child Health Hospital were selected. The relationship between VAIN and TCT, HR-HPV infection and cervical lesions was analyzed by patients’ data. Results Of the 108 patients, 47 cases (43.52%) were younger than 42 years old, and 61 cases (43.52%) were older than 42 years old. The morbidities of low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL) in patients under 42 years old were significantly lower than those in patients over 42 years old (P 0.05). The diagnostic level of TCT had been continuously improved, and the VAIN level had also been gradually improved simutaneously, and the difference was significant (P<0.05). 78.70% (85/108) of VAIN patients had the symptoms of cervical epithelial lesion with VAIN. With the increase of the grade of cervical lesions, the VAIN level was gradually increased (P<0.05). Conclusions VAIN is associated with age, TCT grade, high risk HPV infection and cervical lesions. Key words: Vaginal intraepithelial neoplasia; Liquid-based cytology; High-risk human papillomavirus; Cervical intraepithelial neoplasia; Histological diagnosis