Clinical syndrome and electroencephalography in one patient with Creutzfeldt-Jakob disease

Objective To study the clinical and EEG characteristics of sporadic Creutzfeldt-Jakob disease (CJD). Methods To analyze the clinical manifestation and EEG character of one case with CJD and review its literature review. Results The initial and prominent symptoms showed the progressive declination in binocular vision and limbs tremor accompanying with unconsciousness. The typical EEG exhibited the paroxysmal periodic waves including high amplitude spike-wave, slow wave, three phases and multiple waves, which became more serious along with the worse state of illness. The Brain MRI showed the ischemic changes in right parietal occipital cortex, the multiple cerebral ischemia, lacunar infarction and malacia in bilateral frontal and parietal cortex, bilateral corona radiata, and the basal ganglia. Also the brain atrophy was found by MRI. Conclusion The characteristic EEG with high amplitude slow wave, three phases and multiple waves can be considered as the important index to diagnose CJD.