Malacia is abnormal softening of a biological tissue, most often cartilage. Usually the combining form -malacia suffixed to another combining form that denotes the affected tissue assigns a more specific name to each such disorder, as follows: Malacia is abnormal softening of a biological tissue, most often cartilage. Usually the combining form -malacia suffixed to another combining form that denotes the affected tissue assigns a more specific name to each such disorder, as follows: