OP-271 APPROPRIATE TIME TO INFUSION OF STEM CELLS FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION

Objective: Stem cell (SC) therapy has emerged as a novel therapeutic treatment alternative for LV dysfunction. With the aid of developing techniques, the approach consists of transplanting SC into infarcted myocardium improve regeneration; rebuild neovascularization and the contractile function. Theoretically, for timing of SC administration after myocardial infarction (MI), the days between the 3rd and 7th seems to be the most appropriate period, at which the inflammatory cytokines increased, cell adhesion and migration are at the highest level, and the matrix collagen synthesis has not increased yet. Therefore, the first week after MI has been selected in most of the intracoronary (IC) SC treatment studies (Table 1). In the meta-analyses, BMSC didn’t have any benefit if they infused in the first days. But, limited numbers of studies are heterogeneous in terms of cell count, selected patients criteria and baseline left ventricular ejection fraction (LVEF). We sought to determine if the first days are better for stem cell infusion when total ischemic time and baseline LVEF to be considered. Methods: A systematic search of electronic medical literature was made to identify the randomized controlled trials with primary end point of LVEF improvement during follow-up for patients with MI undergoing primary coronary intervention (PCI) and who received IC bone marrow (BM) SC. The clinical trials were grouped according to their given stem cell count, stem cell infusion time (early 6 hours).