Release and Rheological Properties of Topical Drugs Part 1: Influence of the surfactant (benzethonium chloride) and temperature on the drug (chlorhexidine dihydrochloride) release kinetics

AbstractThe paper deals with the kinetics of liberation of chlorhexidine dihydrochloride (CHH) from chitosan-based hydrogels in the presence of the substance with antiseptic effect, namely benzethonium chloride at the temperature range 25 – 40 °C. The concentration of the CHH in the system was 0.1 % (w/w). The used benzethonium chloride was in concentration range of 0.1 – 1.0 % (w/w). It was found that the release of CHH is influenced by both factors: the concentration of benzethonium chloride and temperature. The release rate constants increase with increasing temperature and decrease with increasing concentration of benzethonium chloride in hydrogels. The activation energy of the release of the substance CHH from hydrogel is higher for hydrogels with higher content of benzethonium chloride. The activation energies of the benzethonium chloride release from the prepared hydrogels were virtually the same.