Probiotics: A New Strategies for Prevention and Therapy of Diarrhea Disease

In this review the evidence from human clinical sc enarios a nd the impact o f p robiotics to modulate the human gut microecology to pr evention and management of diarrhea disease. Probiotics not only help digestive t ract function, they also reduc e t he p resence of less healthful organisms by com peting with t hem for the limited available space . For t his reason, use o f probiotics can help prevent infectious diarrhea. A ntibiotics can breakdown the balance of m icrobial ec ology o f t he gut b y killing and eradicate beneficial bacteria. When this happens, opportunistic b acteria and harmful yeasts can move i n and flourish.. The development of probiotic, aims to " coin with two f aces or Two S ides of a Coin ", which is accomplished by providing a microbial s timulus to the ho st immune system by means of beneficial live microorganism cul tures that a re characteristic o f the heal thy, human gut microbiota, ie, probiotics and reinforce the different lines of gut defense, which are immune exclusion, immune elimination and immune regulation. They were also s hown to s timulate nonspecific host resistance to mi crobial pathogens, thereby aiding i n pa thogen eradication. Consequently, the best documented clinical trials of probiotics i s in t he treatment of diarrhea. Other health ef fects of probiotic b acteria have not been wel l established. Well- designed placebo-controlled studies w ith validated outcome variables a re needed to determine the health effects o f probiotics.