Encapsulation in chitosan-based polyelectrolyte complexes enhances antidiabetic activity of curcumin

Abstract Low bioavailability, poor aqueous stability and lack of appropriate delivery systems delimit the chemotherapeutic effect of curcumin. In this study, curcumin was encapsulated in chitosan-based polyelectrolyte complexes and its antidiabetic activities were assessed using in vitro α-amylase inhibitory assay and in vivo antihyperglycaemic effect in alloxan-induced rats. Microscopic examination showed nanoformulations (