Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

Pei-Pei Kung,Patrick Bingham,Benjamin J. Burke,Qiuxia Chen,Xuemin Cheng,Ya-Li Deng,Dengfeng Dou,Junli Feng,Gary M. Gallego,Michael R. Gehring,Stephan Grant,Samantha Greasley,Anthony R. Harris,Karen A. Maegley,Jordan L. Meier,Xiaoyun Meng,Jose L. Montano,Barry Morgan,Brigitte S. Naughton,Prakash Palde,Thomas A. Paul,Paul G. Richardson,Sylvie K. Ly Sakata,Alex Shaginian,William K. Sonnenburg,Chakrapani Subramanyam,Sergei Timofeevski,Jinqiao Wan,Wen Yan,Albert E. Stewart

Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

2020

Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal structures were obtained for both compo...

Keywords:

Acetyl-CoA
Cocrystal
A-DNA
Acetyltransferase
Biology
Biochemistry

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