Intermediate 3- (4-chlorobutyl) -1h-5- cyanoindole preparing a ketone hydrochloride Wei Lazuo
2013
The present invention relates to 3- (4-chlorobutyl) -1H-5- cyano-indole Preparation of the compound is prepared antidepressant Wei Lazuo Hydrochloride an important intermediate, the reaction comprising the steps of: sodium borohydride in a solvent and dispersed, followed by addition of trichloroacetic acid organic solution was then added portionwise 3- (4-chlorobutyryl) -1H-5- cyanoindole. The method of the present invention in the manufacture -one hydrochloride Wei Lazuo intermediate 3- (4-chlorobutyl) -1H-5- cyanoindole process, simple operation, low equipment requirements, and high yield, good purity, for industrial production, with significant creative and practical value. Reaction equation is as follows:
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