Vilazodone Hydrochloride

Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder. While it was being studied for generalized anxiety disorder such research had stopped as of 2017. It is taken by mouth. Vilazodone, sold under the brand name Viibryd among others, is a medication used to treat major depressive disorder. While it was being studied for generalized anxiety disorder such research had stopped as of 2017. It is taken by mouth. Common side effects include nausea, diarrhea, and trouble sleeping. Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and SIADH. A withdrawal syndrome may occur if the dose is rapidly decreased. Use during pregnancy and breastfeeding is not generally recommended. It is in the serotonin modulator class of medications and is believed to work both as an SSRI and activator of the 5-HT1A receptor. Vilazodone was approved for medical use in the United States in 2011. It is not approved in other countries as of 2016. In the United States the wholesale cost for a month of medication is about 261 USD. In 2016 it was the 278th most prescribed medication in the United States with more than a million prescriptions. According to two eight-week trials in adults, vilazodone has an antidepressant response after one week of treatment. After eight weeks it resulted in a 13% greater response than placebo. Remission rates, however, were not significantly different versus placebo. According to FDA staff, 'it is unknown whether vilazodone has any advantages compared to other drugs in the antidepressant class.' Development for generalized anxiety disorder (GAD) has been stopped as of 2017. While there is tentative evidence of a small benefit in GAD there is a high rate of side effects. On September 6, 2016, the FDA wrote a letter to Forest Labs about Viibryd. New warnings will be added to the Viibryd label related to a link between the drug and acute pancreatitis. Acute pancreatitis can lead to serious injury and even death. Pancreatitis, especially if it reoccurs, can lead to pancreatic cancer, which is almost always fatal.