Radiosensitization of mouse spermatogenic stem cells by ro-07-0582.

SUZUKI, N., WITHERS, H. R., AND HUNTER, N. Radiosensitization of Mouse Spermatogenic Stem Cells by Ro-07-0582. Radiat. Res. 69, 598-601 (1977) The hypoxic character of the spermatogenic stem cells of the mouse testis was investigated by measuring the effect on radiosensitivity of treatment with the hypoxic cell radiosensitizer, Ro-07-0582 or hyperbaric oxygen (30 psi). The Do values obtained were 181 (161-207) rad for irradiation alone, 140 (133-148) rad for irradiation after treatment with Ro-07-0582, and about 100 rad for irradiation in the presence of hyperbaric oxygen. Ro-07-0582 alone was slightly cytotoxic. The results demonstrate that mouse spermatogenic stem cells are radiosensitized by Ro-07-0582 or hyperbaric oxygen and are not as well oxygenated as other normal tissues.