Correlation between resistin and glucose metabolism in patients with cerebral infarction.

Objective To investigate the clinical significance of serum resistin levels in patients with atherosclerotic cerebral infarction(ACI)and analyse the correlation between resistin and glucose metabolism.Methods Eighty-two patients with ACI and fifty healthy subjects were selected.The level of serum resistin was determined by ELISA.The levels of leptin,insulin,fasting blood glucose(FBG),triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and hs-CRP were also detected.Quantitative insulin sensitivity check index(QUICKI)were calculated.Height,weight,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI)and waist-to-hip ratio(WHR)were measured.Results ①The serum levels of resistin,insulin,FBG,leptin,LDL-C and hs-CRP in ACI group were significantly higher than those in the control group(P0.05),the HDL-C and QUICKI were lower than those in the control group.②Taking the occurrence of ACI as the dependent variable and other markers as the independent variables,multiple Logistic regression analysis was performed and and the results showed that ACI was positively correlated with age,resistin,leptin,hs-CRP,SBP,TG,and LDL-C(P0.05),while negatively correlated with QUICKI(P0.05).③The Single factor linear correlation analysis showed that the resistin had positive correlation with FINS,FBG and had negative correlation with QUICKI.No relationship was found between resistin and Leptin(P0.05).Conclusions The increase of resistin is correlated closely with glucose metabolism,which may play an important role in the development of atherosclerotic cerebral infarction.