Spoof Surface Plasmon Polariton Biosensor Chips for Label-Free Detection of Ovarian Cancer

A new diagnosis approach for ovarian cancer (OC) based on spoof surface plasmon polaritons (SPPs) is proposed and experimentally demonstrated, which is label-free, damage-free, and sensitive. SPPs exhibit high electric field confinement and non-diffraction limit. Due to the resonance of split ring resonators (SRRs), the proposed device further enhances the localized field and thus achieves high sensitivity for biosensing. Normal ovarian, serous ovarian cancer, and ovarian clear cell carcinoma tissues were mounted on the SRRs for detection, and different frequency shifting of 90, 212, and 203 MHz was observed, respectively. This approach may also be suitable for diagnosis of other cancerous tissues.