2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

2′-Deoxy-ADPR, formed from the combined action of NMNAT and CD38 in response to H2O2 signaling, activates TRPM2 ion channel currents more potently than the known agonist ADPR via a deceleration of channel inactivation and a higher average open probability.