Long-term outcomes of alternating chemoradiotherapy in patients with advanced nasopharyngeal cancer: a single-centre experience over the last decade

We assessed the long-term outcomes of alternating chemoradiotherapy (ACRT) using 5-fluorouracil and cisplatin (FP) in 25 patients withstage II or advanced nasopharyngeal cancer treated at our institution between April 1999 and April 2010. Median follow-up duration was87 months (range 2-189). According to the 2009 TNM classification (UICC), six patients were in stage II, nine in stage III, and 10 in stageIV. Treatment completion, response and five-year survival rates were retrospectively assessed. ACRT was performed with a first course ofchemotherapy administered followed by the initial round of radiotherapy (36 Gy). Then, a second course of chemotherapy with additionalradiotherapy (20–30 Gy) was administered, followed by a final third course of chemotherapy. For chemotherapy, 5-fluorouracil (5-FU,800 mg/m2/24 h) was intravenously administered for five days, and cisplatin (CDDP, 50 mg/m2/24 h) was administered on the last twodays. Treatment completion rate was 96% (24 of 25 cases), and the response rate was 100% (CR: 24 cases and PR: 1 case). Additionally,the five-year overall survival rate was 89.3%. We have demonstrated that ACRT is an effective regimen to treat nasopharyngeal cancer,revealing higher treatment completion, response, and five-year overall survival rates compared with other combinatorial radiotherapy andchemotherapy treatment regimens.