Asymmetric Centrosome Behavior in Stem Cell Divisions

Stem cells are well known for their self-renewal ability and differentiation potential. It is critical to regulate stem cell self-renewal and differentiation, both during fast growth in development and tissue homeostasis in adulthood. One way to maintain tissue homeostasis is through asymmetric stem cell division, in which centrosomes play an important role in establishing mitotic spindles by acting as a microtubule organization center (MTOC). In this chapter, the asymmetric behavior of centrosomes during stem cell division will be discussed based on their structural, behavioral, and developmental asymmetry.