Preliminary analysis of the photoreceptor inner/outer segment (IS/OS) layer local deletion in macular

ObJective To study the common etiology and optical coherence tomography (OCT) characteristics of the photoreceptor inner/outer segment (IS/OS) layer local deletion in macular.Methods The clinical data of outpatients from June 2009 to January 2012 in Tianjin Eye Hospital were summarized and analyzed retrospectively,and their OCT examination revealed that the IS/OS layer local deletion and break in macular was not associated with other morphological changes outside the region of retina missing.The history,vision,fundus photography and OCT examination results were extracted from the patient's medical records.Results Ninety-eight eyes of 90 cases showed that visual acuity decreased with blurred vision or immediate shadow.Forty-seven eyes of 47 cases (48.0％) had no clear etiological factors; 18 eyes of 17 cases (18.4％) associated with other types of traumatic retinopathy; 7 eyes of 7 cases (7.1％) had macular hole surgery before; 5 eyes of 5 cases (5.1％) had subhyaloid hemorrhage; 4 cases (8.2％) were welders,both eyes injuring; 4eyes of 3 cases (4.1％) were laser injuries; 3 eyes of 2 cases (3.1％) had recent electrical injuries; 2 eyes of 2 cases (2.0％) were high myopia; 1 eye of 1 case (1.0％) restored from central serous chorioretinopathy; 2 eyes of 1 case (1.0％) were with glaucoma and l eye of l case was with diabetes.Fundus photography showed that 80 eyes of 72 cases could be found round or oval,ill-defined dark yellow changes in macular and the others were without significant changes.All the eyes' OCT examination revealed that the IS/OS layer local deletion and break in macular was not associated with other morphological changes outside the region of retina missing.Conclusions The causes of IS/OS layer local deletion and break in macular are very complicate,and many of them are indefinite.The location can impair visual function more or less.It is possible to use OCT to precisely locate diseased regions,thus providing guidance to the clinical diagnosis and treatment. Key words: Photoreceptor inner/outer segment (IS/OS) layer;  Deletion;  Etiology;  Optical coherence tomography