Thioredoxin specifically cross-desensitizes monocytes to MCP-1

INTRODUCTION Thioredoxin (Trx) is a protein disulfide oxidoreductase secreted by various cells including tumor cells, macrophages and lymphocytes. Trx catalyzes the oxidation-reduction of protein disulfides through an active site which has a CGPC motif [1, 2]. This CGPC motif belongs to the family of CXXC motifs which is present in all protein disulfide oxidoreductases including glutaredoxins and protein disulfide isomerase [3], as well [...]