Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14

Xudong Chen,Yue Wang,Yu-Zen Chen,Brian L. Harry,Akihisa Nakagawa,Eui Seung Lee,Hongyan Guo,Ding Xue

Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14

2016

Xudong Chen
Yue Wang
Yu-Zen Chen
Brian L. Harry
Akihisa Nakagawa
Eui Seung Lee
Hongyan Guo
Ding Xue

Perinuclear localization of CED-3 zymogen in C. elegans germ cells and interaction with nuclear-pore protein NPP-14 inhibit autocatalytic activation of CED-3, a central event in apoptosis.

Keywords:

Proteases
Caspase 2
Nuclear membrane
Molecular biology
Caspase
Apoptosis
Zymogen
NLRP1
Cell biology
Biology
Cleavage (embryo)
Caenorhabditis elegans

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