SISTEMA: A Large and Standardized Collection of Transcriptome Datasets for Human Pluripotent Stem Cell Research

Human pluripotent stem cells have ushered in an exciting new era for disease modelling, drug discovery and cell therapy development. Continued progress toward realizing the potential of human pluripotent stem cells will be facilitated by robust datasets and complementary resources that are easily accessed and interrogated by the stem cell community.In this context, we present SISTEMA, a quality-controlled curated gene expression database, built on a valuable catalogue of human pluripotent stem cell lines and their derivatives for which transcriptomic analyses have been generated using a single experimental pipeline. SISTEMA functions as a one-step resource that will assist the stem cell community to easily evaluate the expression level for genes of interest, while comparing them across different hPSC lines, cell types, pathological conditions or after pharmacological treatments.