Statistically validated chromatographic study of salicylate and aniline derivatives of NSAID

A simple, precise and sensitive thin layer chromatographic experiment (TLC) had been carried out for qualitative determination of paracetamol and aspirin in pure also in pharmaceutical dosage form. The experiment was carried out using two different solvent systems used as mobile phase with the determination of Rf value. The experimented Rf value were then validated with different statistical parameters like Precision, Robustness and linearity. The proposed method was found to be precised with a single set of solvent system for pure products. Also with that solvent system it was evident that if a single fraction of that mobile phase was changed in terms of concentration still the method gave robust result. Also the method shows linearity with that solvent system after experimented with a single fraction of solvent of that solvent system. So this method can be followed with that solvent system for the drug paracetamol and aspirin which shall show satisfactory result.