A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.

Jeehyun Yoon,Oleg V. Grinchuk,Srinivasaraghavan Kannan,Melgious Jin Yan Ang,Zhenglin Li,Emmy Xue Yun Tay,Ker Zhing Lok,Bernice Woon Li Lee,You Heng Chuah,Kimberly Chia,Roberto Tirado-Magallanes,Chenfei Liu,Haonan Zhao,Jin Hui Hor,Jhin Jieh Lim,Touati Benoukraf,Tan Boon Toh,Edward Kai-Hua Chow,Jean-Paul Kovalik,Jianhong Ching,Shi-Yan Ng,Ming Joo Koh,Xiaogang Liu,Chandra S. Verma,Derrick Sek Tong Ong

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution.

2021

Glioblastoma (GBM) is a uniformly lethal disease driven by glioma stem cells (GSCs). Here, we use a chemical biology approach to unveil previously unknown GBM dependencies. By studying sulconazole ...

Keywords:

Dependency (UML)
Distribution (pharmacology)
Biotin
Glioma
Chemical biology
Stem cell
Cancer research
Glioblastoma
Sulconazole
Biology

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