Management of anticoagulation in patients with metastatic castration–resistant prostate cancer receiving abiraterone + prednisone

Purpose Abiraterone has been proven to be an effective agent used in the management of metastatic castration–resistant prostate cancer, significantly improving overall and progression-free survival. Due to the pharmacodynamic and pharmacokinetic properties of abiraterone, concurrent use with anticoagulation may pose a challenge for clinicians. Thrombosis within the cancer setting continues to increase patient mortality; therefore, appropriate anticoagulation through the use of a management algorithm can reduce adverse events and increase quality of life.