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Castration

Castration (also known as orchidectomy) is any action, surgical, chemical, or otherwise, by which an individual loses use of the testicles: the male gonad. Surgical castration is bilateral orchidectomy (excision of both testes), and chemical castration uses pharmaceutical drugs to deactivate the testes. Castration causes sterilization (preventing the castrated person or animal from reproducing); it also greatly reduces the production of certain hormones, such as testosterone. Surgical castration in animals is often called neutering. Castration (also known as orchidectomy) is any action, surgical, chemical, or otherwise, by which an individual loses use of the testicles: the male gonad. Surgical castration is bilateral orchidectomy (excision of both testes), and chemical castration uses pharmaceutical drugs to deactivate the testes. Castration causes sterilization (preventing the castrated person or animal from reproducing); it also greatly reduces the production of certain hormones, such as testosterone. Surgical castration in animals is often called neutering. The term castration is sometimes also used to refer to the removal of the ovaries in the female, otherwise known as an oophorectomy or, in animals, spaying. Estrogen levels drop precipitously following oophorectomy, and long-term effects of the reduction of sex hormones are significant throughout the body. The term castration may also be sometimes used to refer to emasculation where both the testicles and the penis are removed together. In some cultures, and in some translations, no distinction is made between the two. This can cause confusion. Castration of non-human animals is intended to favor a desired development of the animal or of its habits, as an anaphrodisiac or to prevent overpopulation. As above, see neutering for more information on castration of non-human animals. Castration was frequently used for religious or social reasons in certain cultures in Europe, South Asia, Africa, and East Asia. After battles in some cases, winners castrated their captives or the corpses of the defeated to symbolize their victory and seize their 'power'. Castrated men — eunuchs – were often admitted to special social classes and were used particularly to staff bureaucracies and palace households: in particular, the harem. Castration also figured in a number of religious castration cults. Other religions, such as Judaism, were strongly opposed to the practice. The Leviticus Holiness code, for example, specifically excludes eunuchs or any males with defective genitals from the priesthood, just as castrated animals are excluded from sacrifice. Eunuchs in China had been known to usurp power in many eras of Chinese history, most notably in the Later Han, late Tang and late Ming dynasties. There are similar recorded Middle Eastern events. In ancient times, castration often involved the total removal of all the male genitalia. This involved great danger of death due to bleeding or infection and, in some states, such as the Byzantine Empire, was seen as the same as a death sentence. Removal of only the testicles had much less risk. Either surgical removal of both testicles or chemical castration may be carried out in the case of prostate cancer. Testosterone-depletion treatment (either surgical removal of both testicles or chemical castration) is used to slow down the cancer, greatly reduce sex drive or interest in those with sexual drives, obsessions, or behaviors, or any combination of those that may be considered deviant. Castration has also been used in the United States for sex offenders.

[ "Prostate cancer", "Testosterone", "Hormone", "177Lu-PSMA-617", "Sipuleucel-T", "Emasculator", "Apalutamide", "Androgen receptor signaling pathway" ]
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