Compounds and compositions for modulating egfr mutant kinase activities

The present invention, cell proliferative diseases and disorders provides a useful protein kinase inhibitors, amino-pyrimidine derivatives, and pharmaceutically acceptable salts for the treatment of a new group (e.g., cancer and autoimmune disease). The present invention provides a composite and method of administration of the protein kinase inhibiting compound. The invention also provides a pharmaceutical composition comprising one or more of the protein kinase inhibiting compound together with a pharmaceutically acceptable carrier, diluent or excipient for this. The present invention also provides useful intermediates produced during the synthesis of the amino-pyrimidine derivatives.