Tumor-homing Stem Cell Therapy for Brain Cancer

Purpose of Review Emerging evidence has demonstrated that genetically engineered stem cells have unique tumor-homing capacity that allows them to deliver anticancer gene products directly into local and invasive glioblastoma foci. New clinical trials have been launched based on the strength of promising preclinical studies. As such, the focus of the present review is to illustrate how stem cells can be used for the treatment of glioblastoma, various features of the stem cell that make them ideal drug delivery vehicles, modes of action, and recent clinical applications.