Pharmacokinetics of Anticancer Drugs in Children

Several comprehensive reviews of the disposition of anticancer drugs in children with cancer have been published (1–7). However, recent advances in cellular and molecular biology techniques have led to the design and analysis of clinical pharmacology studies, which have increased our understanding of the age-related changes that govern drug disposition: absorption, distribution, metabolism, and elimination. Moreover, recent studies have characterized the disposition of new anticancer drugs in children, as well as contributed new insights into the use of currently available anticancer drugs. Thus, an update on pediatric pharmacokinetics of anticancer drugs in children is warranted.