Atipia de clulas glandulares em esfregaos do colo do tero: avaliao dos mtodos propeduticos

ABSTRACT Purpose: to evaluate the diagnostic procedures used inwomen with Pap smear result of atypical glandular cells. Patients and Methods: a prospective study with 159 womenwith atypical glandular cells was carried out betweenJanuary and December 2000. All women were submitted to anew colpocytology and to colposcopy. Directed biopsy wasperformed in 50 cases, endocervical curettage in 21 andconization in 75. The performance of the diagnosticprocedures was described by estimating the sensitivity,specificity, predictive values and likelihood ratio,considering histological results as gold standard. Results: the histological evaluation showed 51 intraepithelialsquamous lesions, 29 low grade and 22 high grade. Fivewomen presented in situ adenocarcinoma and six patientspresented invasive neoplasias. Colpocytology alone showedsensitivity and specificity of 88.5 and 39%, respectively, andcolposcopy alone, 74 and 42%. The association ofcolpocytology with colposcopy increased the sensitivity to98.4%, with a significantly lower specificity of 10%.Endocervical curettage showed low sensitivity (25%).