Prior Carpal Tunnel Syndrome and Early Concomitant Echocardiographic Findings Among Patients with Cardiac Amyloidosis.

Abstract We aimed to characterize patients with systemic amyloidosis stratified by a prior diagnosis of carpal tunnel syndrome (CTS) and to describe early echocardiographic parameters concomitant with CTS. Patients with suspected amyloidosis during CTS diagnosis were excluded. Our cohort included 108 patients with systemic amyloidosis of which 36% had a prior CTS at a median of 4 (IQR 2.8, 6.7) years before disease diagnosis. Patients with prior CTS were more likely to present subsequently with cardiac amyloidosis (78% versus 53%, p =0.013), yet overall survival was comparable between groups (53% versus 61%, p=0.825). Prior CTS was more commonly diagnosed in subsequent transthyretin (ATTR) patients (62%) than in immunoglobulin light chain (AL) patients (24%; p