Abstract 15655: Thrombin Induces Expression Of Sphingosine Kinase-1 (SPHK-1) In Human Vascular Smooth Muscle Cells Via The mRNA Stabilising Protein HuR. Inhibition By Dabigatran Reduces Vascular SPHK-1 Expression And Atherosclerotic Burden In Vivo

2011

Objective: Sphingosine-1-phosphate (S1P) is a cellular signaling lipid generated by sphingosine kinase-1 (SPHK-1). This study investigated the potential regulation of SPHK-1 in thrombin-stimulated ...

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