An observation of anatomical clustering in inputs to primary motor cortex in cortico-cortical brain surface evoked potentials

We present the case of a patient who underwent placement of an electrocorticographic grid for seizure focus localization. Single-pulse electrical stimulation pulses were delivered throughout the grid, and evoked potentials in response to this stimulation were measured from a pre-central gyral, primary motor, electrode. A range of six different general evoked potential responses were observed. Stimulation sites that produced each response type were noted to cluster anatomically, suggesting different potential connectivity motifs between each brain region with primary motor cortex. This observation is an introduction to the presentation KJM will give at the 7th International Winter Conference on Brain-Computer Interface at High1 in Korea, titled “The relationship between task-inferred connectivity and cortico-cortical evoked potentials in human motor cortex.”