Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation.

A 13-year-old patient with transfusion-dependent β thalassemia major developed acute regimen-related lung toxicity after the conditioning regimen but before allogeneic bone marrow transplantation. He was successfully managed on non-invasive ventilatory support. Advances in non-invasive ventilatory support may drastically improve the outlook of this subset of patients who otherwise have a grim prognosis.