Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines

Abstract The chiral carbocyclic nucleosides 2 and 3 were prepared from aristeromycin. The 4′α-hydroxy compound 2 displays good antiviral activity against HSV-1 and HSV-2 with low toxicity.