The mesenchymal-to-epithelial reverting transition is enriched in metastatic castration resistant prostate cancer and correlates with poor survival
2015
Despite recent recognition that
the epithelial-mesenchymal transition
(EMT) program acts in a dynamic manner
(termed Epithelial to Mesenchymal Plasticity
or EMP) during carcinoma metastasis,
it has largely been ignored in the discovery
and development of EMT-targeted therapies.
In part, this has stemmed from a lack
of preclinical models that can mimic the
full dynamic nature of EMP and the perception
that the EMT-reverting transition
[or mesenchymal-epithelial reverting transition;
(MErT)] is a mere antithesis of
EMT. The objective of this study was to
develop the first PCa model capable of
recapitulating the dynamic nature of EMP.
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