Green flourescent protein-tagged liver cells: A new way to study hepatocyte transplantation

compared to its normal counterpart HIPEC. Among the most abundantly increased (greater than 6 fold) transcripts were the TIMP3, MIP3~, and IL10 inducible chemokine (SCYA16), retinoic acid receptor beta, RAB33 (RAS oncogene). Among the most underexpressed (at least 6 fold less than control) genes were interferon induced protein 56 (IFIT1), presenilin-2 (PSEN2), VCAM1, MYBL2, SOD3, RAN (RAS oncogene), and FOSL1. Additionally, the telomerase activity assay demonstrated the presence of active telomerase in HITECs but not in HIPECs. CONCLUSION: Our model of paired HIPEC and HITEC lines will serve as a valuable tool for the identification of the origin of pathological processes in intestinal tumors.