Correlation of adipokines with obesity indices and lipid profile inchronic kidney disease

Introduction and Aim:Adipokines are proposedto be involved in the pathogenesis of chronic kidney disease (CKD) and its association with cardiovascular disease. In the present study, we aimed to assess the levels of adiponectin and resistin in CKD patients and find the correlation of these adipokines with obesity indices, serum lipid profile, and CKD progression. Materials and Methods:Twenty-six each of CKD patients of stages 2 and 3 (Group-I), stages 4 and 5 (Group-II) and healthy controls (Group-III) were the subjects of this study. In the studysubjects, body mass index (BMI), waist to hip ratio (W/H), serum levels of triglycerides, total cholesterol, LDL cholesterol, HDL cholesterol, adiponectin, and resistin were measured. Results:We observed a significant increase in adiponectin, resistin, total cholesterol, triglycerides, and LDL cholesterol, and a decrease in HDL cholesterol in CKD patients when compared to controls (P <0.001). There was a significant negative correlation of adiponectin with total cholesterol, triglycerides, and LDL cholesterol in CKD patients. Serum adiponectin level differed significantly between groups I and II, indicating its positive correlation with the progression of CKD. Conclusion:The present study revealed dyslipidemia and altered levels of adipokinesin CKD. Findings of correlation of adiponectin with lipid profile and CKD stages could have implications in utilizing adiponectin as a diagnostic and prognostic biomarker of CKD. Future studies with a larger sample size, including all stages of CKD and assessing the risk factors are required. Keywords:Adiponectin; chronic kidney disease; lipid profile; obesity; resistin.