Immunological regulation of mesenchymal stem cell

Besides the haemopoietic stem cell, mesenchymal stem cell (MSC) is an adult stem cell in the marrow. It has the ability to self-renew, differentiate into various kinds of tissue and regulate the immunological system. MSC possess low immunogenicity. It shows the immunosuppressive ability in vitro and has function of inducing immune-tolerance. MSC suppress accrementition of T cell respone to the allotigen and mitogen and hinderes the development of cytotoxic T lymphocyte cell. In addition, MSC can influence antigen presenting cell, natural kill cell, B cell, and so on. Key words: mesenchymal stem cell;  immunological regulation;  immune suppression