Phenotypic lentivirus screens to identify functional single domain antibodies

Florian I. Schmidt,Leo Hanke,Benjamin Morin,Rebeccah Brewer,Vesna Brusic,Sean P. J. Whelan,Hidde L. Ploegh

Phenotypic lentivirus screens to identify functional single domain antibodies

2016

Florian I. Schmidt
Leo Hanke
Benjamin Morin
Rebeccah Brewer
Vesna Brusic
Sean P. J. Whelan
Hidde L. Ploegh

A lentiviral screening platform for camelid-derived antibody fragments (VHHs) identifies 19 antiviral VHHs that protect human cells from influenza A virus or vesicular stomatitis virus by preventing vRNP nuclear import or mRNA transcription.

Keywords:

Antibody
Phenotype
Vesicular stomatitis virus
Nuclear transport
Messenger RNA
Influenza A virus
Biology
Lentivirus
Transcription (biology)
Virology
Molecular biology
Ribonucleoprotein
Nucleoprotein
RNA
Single-domain antibody

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