IgM nephropathy with nephrotic syndrome in children

Objective To investigate the clinical charactors and treatment of IgM nephropathy with nephrotic syndrome(NS)in children. Methods Thirty-six IgM nephropathy patients hospitalized in Hunan Children's Hospital as research group(group A), from June 2005 to June 2012.One hundred and six patients with minimal change disease(MCD)as control group(group B), followed up for 1~8 years. Results (1)Hematuria at presentation of the two groups respectly 3.8% vs 30.6%(χ2=20.403, P 0.05). Conclusion Incidence of hematuria is higher in IgM nephropathy patients and patients with renal pathology for moderate lesions have a high steroid-resistant, and need use immunosuppressive early.MMF may be a good immunosuppressive for theses patients. Key words: Nephrotic syndrome; IgM nephropathy; Renal pathology; Steroid- resistant; Mycophenolate mofetil; Children