Cholesterol turnover in hereditary crystalline corneal dystrophy of Schnyder.

SUMMARY Apatientwithhereditarycrystallinecornealdystrophy ofSchnyder required penetrating keratoplasty because of poor visual acuity.Blood cholesterol was labeled with 14C-cholesterol and 11 dayslater a penetrating keratoplasty was done. Atthe time of surgery,corneal levels ofcholesterol were muchhigher than serum levels,showingthatthe corneais anactive site for the uptakeand storage ofcholesterol in this disorder. REFERENCES1. FryWE, Pickett WE: Crystalline Dystrophyofthe Cornea. TransAm Ophthal- mol Soc 48:220-227, 1950.2. KeeneyAH: "Wilfred E. Fry, M.D." TransAm Ophthalmol Soc 74:5-7, 1977. 3. Blodi FC, Yarborough JC: Ocular Manifestations of Familial Hypercholes-terolemia. TransAm Ophthalmol Soc 60:304-315, 1962.4. van Went J, Wibaut F: Een zeldzame erfelijke hoornvliesaandoening. NedTijdschr Geneeskd68:2996, 1924. 5. Schnyder WF: ScheibenformigeKristalleinlagerungen in derHornhautmittealsErbleiden. Klin Monatsbl Augenheilkd 103:494, 1939.6. Bron AJ, Williams HP, Carruthers